迪纳佩尼亚和萨科佩尼亚是间歇性肺部疾病死亡率的危险因素
Alan Aldair Ibarra-Fernández1, Robinson Robles-Hernández2, Arturo Orea-Tejeda3
1Tuberculosis Clinic, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico.
Respirology (Carlton, Vic.)
|February 5, 2025
概括
肌肉衰弱和损失的状况 - - 肌和肉是纤维化间歇性肺病 (ILD) 患者死亡的重要风险因素. 早期发现和治疗这些疾病可能会改善患者的治疗结果.
科学领域:
- 肺部医学 肺部医学
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 纤维化间歇性肺病 (ILD) 呈现出显著的发病率和死亡率.
- 患有ILD的患者经常经历营养状况下降,肌肉衰弱 (肌肉衰弱) 和肌肉衰弱 (肌肉质量损失).
- 这些身体成分变化与肺功能差,运动能力降低和生活质量下降有关.
研究的目的:
- 为了调查ILD患者中dynapenia和sarcopenia的患病率.
- 评估dynapenia和sarcopenia作为ILD死亡率的独立风险因素的影响.
- 分析不同ILD亚型的这些危险因素:异常性肺纤维化 (IPF),结缔组织疾病相关的ILD (CTD-ILD) 和慢性过敏性肺炎 (CHP).
主要方法:
- 未来的队列研究设计.
- 纳入标准:年满18岁且确诊有ILD的患者.
- 排除标准:癌症,艾滋病毒,神经疾病. 使用EWGSOP2标准评估的动脉和肉症.
主要成果:
- 该研究包括98名ILD患者 (平均年龄63.89岁,37.76%男性).
- 动力的患病率为45% (IPF51%,CTD-ILD35%,CHP61%). 麻症的患病率为29% (IPF为39%,CTD-ILD为14%,CHP为50%).
- 鉴定出 (HR:2.04) 和肉 (HR:1.88) 是独立的死亡风险因素,经过调整以考虑混变量.
结论:
- 动脉和肉是显著的,独立的风险因素,死亡率在患者间歇性肺病.
- 这些发现强调了评估ILD管理中的肌肉健康的重要性.
- 针对dynapenia和sarcopenia的针对性干预可以改善ILD患者的存活率.
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