通过控制血压,恢复肺-血管素系统平衡
Gabriela Catão D Braga1, Joao Carlos Ribeiro-Silva2, Andreia Boaro1
1Laboratório de Genética e Cardiologia Molecular, Faculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Clinical science (London, England : 1979)
|February 5, 2025
概括
控制高血压 (BP) 重新平衡肺氨酸 - 血管增生素系统 (RAS),减少炎症. 这项研究将血压控制与改善肺部健康联系起来,并表明高血压和炎症性肺部疾病之间存在联系.
科学领域:
- 心血管生理学心血管生理学
- 肺炎是一种肺炎.
- 脏生理学 脏生理学
背景情况:
- 失调的氨酸-动脉素系统 (RAS) 信号与高血压 (HTN),炎症和器官损伤有关.
- 患有高血压的个体在肺部表现出经典和对调节RAS成分的改变.
- 高血压,肺炎和COVID-19等疾病之间存在潜在的联系.
研究的目的:
- 调查血压 (BP) 控制是否可以恢复肺部经典 (ACE/Ang II) 和反调节 (ACE2/Ang 1-7) RAS成分之间的平衡.
- 为了确定这种再平衡是否减轻自发高血压大鼠 (SHRs) 的肺炎.
主要方法:
- 男性SHRs被用洛萨坦或阿姆洛迪平治疗以降低BP.
- 测量了肺Ace2和Ace基因表达,肺ACE2的丰度和活性,以及Ang II和Ang 1-7的水平.
- 评估了肺组织中的巨细胞数量和促炎基因表达.
- 血清ACE2水平分析在不同血压控制的人体受试者.
主要成果:
- 降血压治疗 (洛萨坦,安洛迪平) 在SHR中调高肺Ace2和调低Ace表达.
- 肺部ACE2的丰度和活性增加,而Ang II下降,Ang 1-7增加.
- 重新平衡的肺RAS导致肺巨细胞和促炎性基因表达的减少.
- 在人类不受控制的高血压中观察到更高的循环ACE2水平.
结论:
- 使用RAS抑制剂或通道阻断剂控制高血压可以使SHRs中的肺RAS重新平衡.
- 这种重新平衡缓解了肺炎,这表明高血压和炎症性肺部疾病之间存在机械联系.
- 这些发现强调了ACE/ACE2失衡在高血压引起的肺炎中的作用.
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