精神病发作时的认知表现,通过病前恶化和暴露于环境风险因素
Laura Ferraro1, Marta Di Forti1,2,3,4, Daniele La Barbera1
1Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), Psychiatry Section, University of Palermo, Palermo, Italy.
Psychological medicine
|February 5, 2025
概括
环境风险因素与第一发精神病 (FEP) 的认知障碍有关. 在FEP患者群体中发现了更高的环境风险得分 (ERS),特别是那些有认知缺陷的患者,这表明了干预的潜在目标.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 环境健康 环境健康
背景情况:
- 之前的研究已经确定了基于认知功能和病前调整的第一发精神病 (FEP) 的患者群.
- 这项研究研究了社会环境风险因素与不同FEP患者集群之间的关联.
研究的目的:
- 为了比较FEP患者集群和社区对照,使用莫德斯利精神病环境风险评分 (ERS).
- 探索区分FEP集群和控制的特定环境风险因素.
主要方法:
- 使用单变量和多变量通用线性模型 (GLM) 来比较1,263个对照组和802名FEP患者之间的ERS,跨定义的群集 (低功能,高功能,中间,恶化).
- 分析了包括父亲年龄,童年逆境,大麻使用和少数民族身份在内的环境风险.
主要成果:
- 所有FEP患者群体都表现出高于对照组的ERS.
- 恶化和低认知功能集群显示显著更高的ERS.
- 与其他集群相比,恶化的集群增加了大麻暴露率和少数民族代表性.
结论:
- 暴露于环境风险因素的增加可能会导致认知障碍和精神病发作时功能减弱.
- 在特定的患者轨迹中识别可修改的风险因素,为量身定制的干预提供了潜力.
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