抑郁症中喜欢食物的变化是由宏观营养素组成驱动的
Lilly Thurn1, Corinna Schulz1,2, Diba Borgmann3
1Section of Medical Psychology, Department of Psychiatry & Psychotherapy, Faculty of Medicine, University of Bonn, Bonn, Germany.
Psychological medicine
|February 5, 2025
概括
患有重度抑郁症 (MDD) 的患者表现出食物奖励灵敏度的改变,特别是对于高脂肪和高蛋白质食物,这表明肠-大脑信号干扰. 这些发现可能会为新的抑郁症治疗方法提供信息.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 营养科学 营养科学
背景情况:
- 大型抑郁症 (MDD) 与食欲和体重的变化有关,与减少奖励敏感性 (无情感) 一起.
- 驱动改变奖励灵敏度的具体机制,特别是与食物有关的,仍然不清楚.
研究的目的:
- 调查食品宏观营养素成分在MDD患者的奖励敏感性改变中的作用.
- 为了比较MDD和健康对照 (HCP) 个体之间的食物想要和喜欢评级.
主要方法:
- 对117名参与者 (54名MDD患者,63名医疗人员) 进行了食物暗示反应任务.
- 参与者对各种食品和非食品物品进行了"想要"和"喜欢"的评分.
- 分析了奖励评级与食品宏观营养素组成 (碳水化合物,脂肪,蛋白质) 之间的关联.
主要成果:
- 与医疗保健工作者相比,患有MDD的患者报告说,与医疗保健工作者相比,他们想要但不喜欢的食物显著减少.
- 宏观营养素组成显著改善了预测想要和喜欢的模型.
- 与碳水化合物相比,MDD患者对高脂肪和高蛋白食物的喜好和渴望减少.
- 在MDD患者中观察到食物偏好的相关性较弱,这表明代谢信号干扰.
结论:
- 与抑郁症相关的食物奖励变化与宏观营养素含量,特别是脂肪和蛋白质含量有关.
- 研究结果表明,在MDD中,肠-大脑信号通路存在潜在的干扰.
- 针对肠道微生物组的干预措施可能是正常化抑郁症中异常食物奖励信号的潜在治疗途径.
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