大型抑郁症中情绪调节网络的功能连接受损及其与症状改善的关联:一项多站式休息状态功能性MRI研究
Zhihui Lan1, Lin-Lin Zhu1, You-Ran Dai1
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Psychological medicine
|February 5, 2025
概括
大型抑郁症 (MDD) 患者在情绪调节网络 (ERN) 中表现出大脑功能连接 (FC) 的改变. 这些异常的FC模式与治疗反应相关,为MDD的神经病理学和治疗机制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 情绪调节网络 (ERN) 对于理解情绪障碍至关重要.
- 关于主要抑郁症 (MDD) 和ERN神经生物学的先前研究是有限的.
- 在ERN中的异常功能连接 (FC) 和其作为MDD治疗标志物的作用尚不清楚.
研究的目的:
- 在MDD患者和健康对照者 (HCs) 之间研究ERN种子的全脑静止状态FC的群体差异.
- 评估MDD中异常ERN FC模式是否可以预测抗抑郁药单一治疗的治疗反应.
主要方法:
- 分析了五个站点的大型fMRI数据集 (709名MDD患者,725名HC患者).
- 采用基于种子的FC方法,使用14种ERN种子.
- 在45名MDD患者的独立样本中验证的发现,评估症状改善.
主要成果:
- 患有MDD的患者在7个ERN种子和各种皮质/皮下皮质区域 (例如,中回,乳头,回) 之间表现出异常的FC.
- 这些异常的ERN FC与治疗后MDD患者的症状减少 (HAMD17得分) 有负相关.
结论:
- 研究结果表明,ERN连接的改变是MDD情绪处理缺陷的基础.
- 异常的ERN FC可能作为MDD治疗反应的神经生物学标志物.
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