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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

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表面工程核心-外向上转换纳米颗粒,用于有效的超素输送和多式成像.

Taras Vasylyshyn1, Veronika Huntošová2,3, Vitalii Patsula1

  • 1Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 00 Prague, Czech Republic. horak@imc.cas.cz.

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概括
此摘要是机器生成的。

这项研究引入了新的上转化纳米粒子 (UCNPs),用于针对性地向瘤输送超素 (Hyp). 这些UCNP增强了光动力学治疗的有效性,并显示了未来癌症治疗应用的前景.

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科学领域:

  • 纳米技术 纳米技术
  • 材料科学 材料科学 材料科学
  • 生物医学工程 生物医学工程

背景情况:

  • 纳米技术加速了癌症的诊断和治疗.
  • 上转化纳米粒子 (UCNPs) 在药物输送和瘤成像方面显示出潜力.
  • 针对性地提供光敏剂对于有效的光动力学疗法至关重要.

研究的目的:

  • 开发一种基于UCNP的新型输送系统,用于将光敏感剂高素 (Hyp) 输送到恶性瘤中.
  • 为了提高光动力学治疗 (PDT) 的有效性,使用UCNP进行向癌症治疗.
  • 评估开发的纳米粒子系统的安全性和有效性.

主要方法:

  • 通过热分解合成核心的NaYF4:Yb3+,Er3+@NaYF4:Nd3+UCNP.
  • 为了稳定性,将UCNP涂上聚N,N-二甲基甲基胺-co-2-氨基乙烯酸) -阿伦德罗酸[P.DMA-AEA) -Ale].
  • 将高素 (Hyp) 与UCNP系统结合,并使用多式成像和MTT检测进行验证.

主要成果:

  • 成功合成和描述载有Hyp.荷载的基于UCNP的纳米粒子.
  • 在Jurkat细胞中使用多式成像技术验证了纳米粒子内部化.
  • 与单独使用Hyp.相比,在辐射后证明了增强的光动力学效应和显著的癌细胞活力降低.
  • 确认的Hyp释放在酸性瘤环境中较高,表明瘤特异性药物输送.

结论:

  • 开发的UCNP@P(DMA-AEA) -Ale-Hyp系统是一个有前途的平台,用于向的高素输送和增强的光动力学癌症治疗.
  • 这些纳米粒子表现出良好的稳定性,细胞吸收和治疗疗效,细胞毒性最小.
  • 瘤特异性释放特征表明,它适合未来在癌症治疗中的体内应用.