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三基酸盐在小鼠中诱导男性生殖毒性

Jiayi Wang¹, Yanfan Cui², Yujie Wang²

¹Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China.

Environmental science & technology

|February 5, 2025

概括

酸三 (TBP) 暴露会通过减少精子数量和运动性来损害男性生育能力. TBP诱导丸损伤,氧化应激和肠道微生物群变化,影响肠-丸轴.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生殖生物学生殖生物学

背景情况:

三聚酸 (TBP) 是一种环境污染物,对男性生殖有未知的影响.
由于TBP的广泛存在,了解其生殖毒性至关重要.

研究的目的:

在小鼠和GC-2细胞中研究TBP的男性生殖毒性.
阐明TBP诱导的生殖损害背后的机制.

主要方法:

向雄性ICR小鼠口服测量TBP,并将GC-2细胞暴露于TBP.
评估精子参数,丸组织学,亡标志物 (BCL2/BAX),活性氧物种 (ROS),线粒体膜潜力,肠道微生物群和炎症标志物 (IL-17A).

主要成果:

暴露于TBP减少了精子数量和运动性,损坏了丸结构,并诱导了小鼠的亡.
TBP抑制了GC-2细胞活力,增加了细胞亡,降低了BCL2/BAX比率,增加了ROS,并降低了线粒体膜潜力.
结核蛋白引起肠道失调,改变了代谢概况,增加了Prevotellaceae,诱导了炎症,Th17细胞透和IL-17A信号传递.

结论:

TBP通过涉及肠-丸轴,氧化应激和亡的机制诱导男性生殖毒性.
TBP对雄性哺乳动物构成繁殖危险,强调需要进一步评估环境风险.

关键词:

在GC-2细胞中.三聚酸三聚酸三聚酸肠-试管道毒性轴毒性轴鼠标鼠标鼠标鼠标氧化应激是一种氧化应激.

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