相关实验视频

Updated: Jun 15, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

免疫疗法时代的可切除的鼻粘膜黑色素瘤:前置手术与新辅助疗法

Aya F Salem¹, Melissa M Chen², Michelle D Williams³

¹Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

|February 5, 2025

概括

尽管接受了免疫疗法,可切除鼻未分化癌 (SNUC) 的结果仍然很差. 虽然新辅助药伊皮利马布/尼沃马布 (Ipi/Nivo) 没有改善整体结果,但显示出反应的患者的预后更好.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
手术瘤学手术瘤学

背景情况:

鼻未分化癌 (SNUC) 是一种罕见且具有攻击性的恶性瘤.
免疫疗法时代为各种癌症引入了新的治疗模式.
用免疫治疗治疗的切除性SNUC评估结果至关重要.

研究的目的:

在免疫疗法时代评估可切除SNUC患者的治疗结果.
调查新辅助药伊皮利马布/尼沃马布 (Ipi/Nivo) 对该患者队列结果的影响.

主要方法:

对37名在2016年至2023年期间接受治疗的可切除SNUC患者的回顾性审查.
对接受新辅助药伊皮利马布/尼沃马布 (Ipi/Nivo) 的患者进行分析.
评估应答率,局部无复发生存率 (LRFS) 和无进展生存率 (PFS).

主要成果:

接受新辅助Ipi/Nivo治疗的患者更有可能患有涉及鼻腔和骨底部的疾病 (71%对35%).
对Ipi/Nivo的整体反应率为24%.
两年的LRFS为63%,PFS为49%. 有Ipi/Nivo反应证据的患者显著改善了PFS (100%vs.15%) 和LRFS (100%vs.31%).

结论:

在免疫疗法时代,切除性SNUC患者的结果仍然很差.
新辅助Ipi/Nivo并未与所有患者的改善结果相关,这可能是由于选择偏差.
对Ipi/Nivo反应的证据表明,可切除SNUC患者的预后更好.

关键词:

免疫检查点抑制抑制免疫检查点抑制新辅助免疫疗法新辅助免疫疗法鼻腔黑色素瘤是什么意思

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...