纤维化在体外和体外模型:通往生理学相关的人性化模型的道路
Gabriele Addario1, Lorenzo Moroni1, Carlos Mota1
1Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, ER Maastricht, 6229, The Netherlands.
Advanced healthcare materials
|February 5, 2025
概括
先进的3D模型为研究慢性病 (CKD) 和纤维化提供了改进的人体生理模拟. 这些模型有望为纤维化治疗提供更好的药物开发,解决当前2D和体内方法的局限性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物医学工程 生物医学工程
- 翻译医学是一种翻译医学.
背景情况:
- 慢性病 (CKD) 影响全球人口的10%以上,纤维化是疾病进展和死亡的一个关键因素.
- 目前的研究模型,包括体内和2D体外系统,在完全复制人类脏生理学,新陈代谢和分子途径方面存在局限性.
- 临床试验中许多疗法的失败强调了研究纤维化的更先进模型的需要.
研究的目的:
- 审查研究纤维化现有的二维和体内模型的局限性.
- 探索最先进的3D人性化体外模型的潜力,以推进病研究.
- 突出这些先进模型如何改善纤维化治疗的翻译.
主要方法:
- 对病模型的当前文献的综述,包括2D细胞培养和体内研究.
- 探索先进的3D体外建模技术,如3D细胞聚合物,器官在芯片上和生物制造.
- 讨论病的诊断方法,包括生物标志物分析和组织活检.
主要成果:
- 现有的二维和体内模型无法充分反映人类脏的复杂性和功能,阻碍了翻译研究.
- 3D人性化体外模型,包括有机体和生物工程结构,在模仿脏形态发生和功能方面表现有前途.
- 这些先进的模型为研究纤维化机制提供了一个更具生理相关性的平台.
结论:
- 先进的3D体外模型代表了对研究纤维化的传统方法的显著改进.
- 这些模型有可能加速慢性病新疗法的开发和临床转化.
- 进一步开发和验证3D脏模型对于推进脏学研究和患者护理至关重要.
相关概念视频
00:57Deindividuation
Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.
01:21Mechanistic Models: Overview of Compartment Models
Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
01:23Mechanistic Models: Compartment Models in Individual and Population Analysis
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
01:26Pharmacokinetic Models: Comparison and Selection Criterion
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
01:23Carl Rogers' Humanistic Perspective on Personality
Carl Rogers, a key figure in humanistic psychology, believed that individuals possess an innate potential for growth and fulfillment. According to his model of personality, three significant components define an individual: the organism, the self, and conditions of worth.
The organism refers to an individual's inherent blueprint, which Rogers saw as innately positive and directed toward helping others, unlike Freud's view of the id as driven by base impulses. The self is a person's...
The organism refers to an individual's inherent blueprint, which Rogers saw as innately positive and directed toward helping others, unlike Freud's view of the id as driven by base impulses. The self is a person's...
01:21Factors Influencing Attraction II: Physical Attraction
Physical attractiveness plays a crucial role in shaping interpersonal attraction, influencing first impressions, social interactions, and long-term relationship dynamics. Psychological research consistently demonstrates that attractiveness affects social evaluations and behavioral outcomes in various contexts.Influence on Social InteractionsResearch has shown that individuals perceived as physically attractive often experience preferential treatment in social and professional settings. One...