精子DNA碎片化指数对辅助生殖结果的影响:回顾性分析
Bin Yang1, Leizhen Xia1, Rufei Deng2
1Center for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, China.
Frontiers in endocrinology
|February 5, 2025
概括
精子DNA碎片化指数 (DFI) 影响了IVF中的胚胎发育,但并没有影响怀孕的成功. 高DFI与低出生体重婴儿有关,因此需要进一步研究其在辅助生殖结果中的作用.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精 (IVF)
背景情况:
- 精子DNA碎片化指数 (DFI) 在男性生育能力中的临床意义受到争议.
- 了解DFI对试管婴儿结果和潜在的长期孕产妇和新生儿并发症的影响至关重要.
研究的目的:
- 调查精子DFI和精液参数之间的关联.
- 评估DFI对胚胎发育和IVF后怀孕结果的影响.
- 评估DFI对孕产妇和新生儿并发症的潜在影响.
主要方法:
- 分析了5,271名首次试管婴儿患者的数据.
- 根据精子DFI水平 (<15%,15-30%,≥30%) 将参与者分为三组.
- 多变量后勤回归用于分析DFI,精液参数,胚胎发育,临床结果和并发症之间的相关性.
主要成果:
- 精子DFI与精液质量负相关.
- 较高的DFI水平与胚胎细胞形成和可转移胚胎率的减少有关.
- 没有观察到怀孕结果的显著差异,但高的DFI增加了低出生体重婴儿的风险.
结论:
- 精子DFI影响胚胎发育,并与低出生体重的风险增加有关.
- DFI似乎不会影响临床妊娠结果或其他产周并发症.
- 需要进一步的大规模研究来澄清DFI在辅助生殖中的预测作用,特别是对后代的结果.
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