月经障碍和抗穆勒尔激素与COVID-19之间的关联:一项前性队列研究
Ziba Haghipour1, Shahideh Jahanian Sadatmahalleh1, Fatemeh Razavinia2
1Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
International journal of reproductive biomedicine
|February 5, 2025
概括
COVID-19显著影响女性的生殖健康,导致感染后抗穆勒尔激素 (AMH) 水平降低,甲状腺刺激激素 (TSH) 水平提高. 这些荷尔蒙变化凸显了针对性卫生政策的必要性,以减轻长期并发症.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 传染性疾病 传染性疾病
背景情况:
- 由于COVID-19的流行,造成了广泛的健康问题,影响了各种身体系统.
- COVID-19对女性生殖和内分泌系统的长期影响需要进一步调查.
研究的目的:
- 评估COVID-19对月经障碍的影响.
- 评估COVID-19感染后女性抗穆勒尔激素 (AMH),甲状腺过氧化酶 (TPO),甲状腺刺激激素 (TSH) 和益生素水平的变化.
主要方法:
- 进行了一项前性队列研究,涉及201名女性 (100名COVID-19患者,101名健康对照).
- 月经周期数据和血液样本用于激素水平分析 (AMH,TSH,TPO,益生菌素) 在康复1个月和4个月后收集.
主要成果:
- 两组之间没有发现月经障碍或TPO和益生菌水平的显著差异.
- 与健康对照组相比,COVID-19患者的AMH水平在1个月和4个月内显著降低.
- 在感染后1个月观察到高TSH和COVID-19之间的显著关联,该关联减少了4个月.
结论:
- COVID-19与内分泌功能障碍有关,其特征是AMH降低和TSH水平升高.
- 这些发现强调了在COVID-19后监测女性荷尔蒙和月经健康的重要性.
- 卫生政策制定者应该解决这些内分泌和月经并发症,以减少长期的健康负担.
相关概念视频
02:07Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
01:22Hormonal Regulation of the Menstrual Cycle
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
01:24Disorders of the Female Reproductive System
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...