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Updated: May 29, 2025

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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结合CRISPR激活和干扰功能使用dCas9和G-四重复结构

Mohammad Lutful Kabir1, Sineth G Kodikara2, Mohammed Enamul Hoque1

  • 1Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, United States.

NAR molecular medicine
|February 5, 2025
PubMed
概括

集群定期间隔的短平行体重复 (CRISPR) 干扰和激活,针对dCas9有效调节基因表达的c-Myc促进体. 这种CRISPR-dCas9系统在细胞和体外研究中显示出显著的c-Myc抑制和激活.

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