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炎症性肠病中小肠细菌过度生长的流行率和预测因素:一个元分析
Xin Feng1, Jie Hu2, Xin Zhang1
1Department of Gastroenterology, The People's Hospital of Yubei District of Chongqing City, Chongqing, China.
Frontiers in medicine
|February 5, 2025
概括
小肠细菌过度生长 (SIBO) 影响了近三分之一的炎症性肠病 (IBD) 患者. 预测因素包括较低的BMI,胀气和之前的腹部手术.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 内部医学 内部医学
背景情况:
- 小肠细菌过度生长 (SIBO) 经常在炎症性肠病 (IBD) 患者中观察到.
- 在IBD中SIBO的患病率在不同研究中差异很大.
研究的目的:
- 为了确定IBD患者中SIBO的综合流行率.
- 在IBD患者中确定SIBO的预测因子.
主要方法:
- 在PubMed,Cochrane图书馆和EMBASE进行了系统的文献搜索,截至2024年3月.
- 在IBD和对照中计算了SIBO的聚合流行率和几率比率 (OR).
- 在IBD患者中评估了SIBO的预测因素.
主要成果:
- 分析了29项研究,包括3,250名IBD患者和708名对照患者.
- 在IBD中SIBO的综合流行率为31.0%,明显高于健康对照组 (OR5.25).
- 在IBD中SIBO的预测因素包括较低的BMI,膨胀,浮,腹部手术史和严格的/透的疾病行为.
结论:
- 大约三分之一的IBD患者患有SIBO,与健康个体相比,其几率增加了5.25倍.
- 在IBD患者中,SIBO的关键预测因素被确定为较低的BMI,胃肠道症状和手术史.
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