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尼特洛克在体外对抗中国分离的尿病原体的抗菌活性

Xiaofei Yi¹, Xin Chen¹, Yanyan Lu¹

¹Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 20040, China.

JAC-antimicrobial resistance

|February 5, 2025

概括

尼트로林在体外表现出强烈的活性,对抗来自中国的常见尿路感染病原体,包括Acinetobacter baumannii. 这表明氧可能是无并发性尿路感染的有价值的治疗选择,特别是那些由具有挑战性的细菌引起的.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

尼特洛克是一种用于欧洲无并发性尿路感染 (UTI) 的抗菌药物.
对于来自中国的泌尿病原体,存在有限的体外抗菌数据.
这项研究解决了对尼特洛克索林对中国尿路病原体的疗效数据的需求.

研究的目的:

为了研究氧在中国患者中隔离的泌尿病原体的体外抗菌活性.
评估尼托克索林作为中国无并发性尿路感染治疗的潜力.

主要方法:

通过使用微稀释,对229个细菌分离物 (10个物种) 确定了尼托克索林的最小抑制度 (MIC).
适用于所有分离物对大肠杆菌 (16 mg/L) 的EUCAST敏感度断点.
确定了Acinetobacter baumannii的最小杀菌度 (MBC) 和杀死时间曲线.

主要成果:

除了Pseudomonas aeruginosa外,大多数隔离物对氧敏感.
对于大肠杆菌,Klebsiella pneumoniae和Proteus mirabilis的MIC50/90值分别为4/8,8/32和8/16毫克/升.
尼托克索林对Acinetobacter baumannii (MIC50/90: 2/2 mg/L) 具有强烈的活性,其杀死程度取决于度.

结论:

尼托克索林在体外表现出极好的抗中国尿病原体的活性.
它可能是无并发性尿路感染的可行选择,特别是那些由Acinetobacter baumannii引起的.
需要进一步的体内疗效研究来证实临床效用.

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