美国退伍军人在慢性乙型肝炎中进行型肝炎病毒检测,流行率和肝脏相关结果
Robert J Wong1,2, Zeyuan Yang2, Janice H Jou3,4
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
Gastro hep advances
|February 5, 2025
概括
在慢性乙型肝炎 (CHB) 患者中,型肝炎病毒 (HDV) 检测水平较低. 高密度病毒感染显著增加了肝硬化和肝衰竭的风险,强调了迅速诊断和治疗的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 肝炎三角病毒 (HDV) 感染加剧了慢性乙型肝炎 (CHB) 患者的肝病.
- 了解HDV对大型队列中肝脏相关结果的影响对于临床管理至关重要.
- 患有CHB的美国退伍军人代表了研究病毒性肝炎联合感染的重要人口.
研究的目的:
- 评估美国退伍军人中患有CHB的HDV测试和诊断的趋势.
- 评估HDV感染与肝脏相关结果之间的关联,包括肝硬化,肝脏衰竭和肝细胞癌.
- 为了确定HDV阳性与HDV阴性CHB患者中不良肝脏结局的发生率.
主要方法:
- 从2010年到2023年对美国退伍军人患有CHB的国家队列进行了回顾性分析.
- 测试率 (抗HDV抗体,HDVRNA) 和阳性的评估.
- 使用竞争性风险分析,对HDV阳性和HDV阴性CHB患者之间的肝脏相关结果进行比较的倾向性匹配得分.
主要成果:
- 只有16.1%的CHB患者接受了HDV检测,阳性率为3.25%.
- 与HDV阴性患者相比,HDV阳性患者的肝硬化发病率 (4.39对1.30每10万人/年) 和肝衰竭 (2.18对0.41每10万人/年) 显着更高.
- 肝细胞癌的发病率也被评估,但在提供的结果中没有详细说明.
结论:
- 在患有CHB的美国退伍军人中观察到低水平的HDV测试.
- 同时的HDV感染与肝硬化和肝脏不补偿的风险大大增加有关.
- 在CHB患者中及时诊断和治疗HDV至关重要,以减轻严重的肝脏相关结果.
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