介素-17在与炎症相关的癌症中的作用
Xingru Zhang1,2, Bangjie Li1, Tian Lan1,2
1The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, China.
Frontiers in immunology
|February 5, 2025
概括
互乐金-17 (IL-17) 是一种关键的细胞因子,可以将炎症与癌症联系起来. 它在促进或抑制瘤生长方面的双重作用取决于背景,影响癌症治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 炎症越来越被认为是癌症发展和进展的驱动因素.
- 介素-17 (IL-17) 细胞因子家族是关键的调解者,将炎症与瘤发生联系起来.
- IL-17在癌症中的作用是复杂的,表现出前瘤和抗瘤效应.
研究的目的:
- 审查IL-17及其癌症受体的基本生物学.
- 讨论最近关于IL-17在炎症相关癌症中的类效应和机制的进展.
- 探索IL-17通过微生物群相互作用对癌症进展的影响及其治疗含义.
主要方法:
- 关于IL-17在癌症中的现有研究的文献评论.
- 在各种癌症中分析IL-17信号通路和受体表达.
- 研究微生物群,IL-17和瘤发育之间的相互作用.
主要成果:
- 在早期瘤发生过程中,IL-17信号可以直接促进瘤细胞的增殖.
- 在某些实验癌症模型中,IL-17已经证明了抗瘤免疫力.
- 微生物组动力学显著影响IL-17分泌和随后的瘤发育.
结论:
- 癌症中IL-17的特定功能取决于情境,因其分类,时空动力学和瘤阶段而有所不同.
- 了解IL-17的多方面的作用对于开发有效的癌症疗法至关重要.
- 准IL-17通路,可能与微生物群调节结合,对癌症治疗具有前途.
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