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胃食道逆流性疾病和慢性阻塞性呼吸道疾病之间的因果关系:双向的门德尔随机化研究
Shan Lin1, Dingfeng Lai2, Wanmei He2
1Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Heliyon
|February 5, 2025
概括
胃食道逆流性疾病 (GERD) 显著增加患慢性阻塞性肺病 (COPD) 和喘的风险. 这项研究证实了因果关系,表明GERD治疗可能有助于预防这些呼吸道疾病.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 胃肠病学 胃肠病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,胃食道逆流性疾病 (GERD) 与慢性呼吸道疾病 (如COPD和喘) 之间存在联系.
- 在GERD和这些条件之间还没有确定的因果关系.
- 调查这种联系对于理解和管理呼吸道疾病至关重要.
研究的目的:
- 为了确定GERD是否会对患上COPD和喘的风险产生因果关系.
- 探索GERD与这些慢性呼吸道疾病之间的潜在双向因果关系.
- 提供关于将GERD管理纳入呼吸道疾病预防和治疗的证据.
主要方法:
- 使用了两个样本的门德尔随机化 (MR) 方法.
- 使用来自欧洲队列的全基因组关联研究数据的双向MR.
- 使用MR-Egger拦截,MR-PRESSO和Steiger测试来评估因果关系,以确认发现并排除偏差.
主要成果:
- 遗传倾向于GERD的个体患上COPD (OR=1.520) 和喘 (OR=1.420) 的风险明显更高.
- 反向MR分析发现,COPD或喘对GERD发病没有显著的因果关系.
- 统计测试证实了异质性和质性缺失,支持了因果发现.
结论:
- 这项研究提供了强有力的证据,证明GERD与COPD和喘风险增加之间存在因果关系.
- 在COPD和喘的预防和治疗策略中应考虑GERD管理.
- 这些发现强调了整体呼吸系统健康方法的重要性,考虑到胃肠道因素.
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