在使用医疗补助数据库的老年人中,在种族/种族之间使用和停止长效注射抗精神病药物的使用率
Christopher M Cassara1, Jianing Xu2, Daniel B Hall3
1College of Pharmacy, University of Georgia, Athens, Georgia, USA.
Journal of the American Geriatrics Society
|February 5, 2025
概括
在老年人中,第一代长期作用的注射抗精神病药物比第二代药物更早地停止使用. 黑人患者更频繁地接受第一代药物,这可能会影响健康结果.
科学领域:
- 精神病学是一个精神病学.
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 长效注射 (LAI) 抗精神病药物对于治疗精神分裂症谱系障碍至关重要.
- 了解老年人处方模式和停药率对于优化治疗至关重要.
研究的目的:
- 分析65岁及以上患者的LAI抗精神病药物处方模式.
- 为了比较不同LAI代理商之间的戒断率,并检查种族/民族差异.
主要方法:
- 利用了Merative MarketScan医疗补助数据库 (2017-2021年) 对65岁以上的患者处方LAI抗精神病药物.
- 采用后勤和Cox比例危险回归来分析种族/种族,LAI生成和停药率.
主要成果:
- 帕利佩里棕酸盐 (1个月),哈洛佩里二甲酸盐和Risperidone微球是最常见的LAI.
- 黑人患者比白人患者更频繁地接受第一代LAI (OR: 1.74).
- 与第二代地方医疗机构相比,第一代地方医疗机构的停药率显著提前 (HR: 2.12).
结论:
- 第一代LAI抗精神病药与第二代药物相比,更早停止治疗有关.
- 在黑人和白人老年人之间观察到LAI抗精神病药物处方的差异,这需要进一步调查潜在的健康结果影响.
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