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循环瘤的健康经济评估癌症查的DNA测试:系统性审查

Mingjun Rui¹, Yingcheng Wang¹, Joyce H S You¹

¹School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China.

Cancer medicine

|February 5, 2025

概括

与传统方法相比,循环瘤DNA (ctDNA) 测试在癌症查中通常不具有成本效益. 特殊情况包括在某些条件下进行mt-sDNA和mSEPT9等特定测试,需要进一步进行经济评估.

科学领域:

在瘤学瘤学.
卫生经济学卫生经济学
生物标志物研究生物标志物研究

背景情况:

癌症检测是全球主要的健康挑战.
循环瘤DNA (ctDNA) 为癌症查提供了一个有前途的非侵入性生物标志物.
评估ctDNA查的经济可行性对于医疗保健政策至关重要.

研究的目的:

系统地审查和描述ctDNA用于癌症查的健康经济评估.
评估不同类型癌症中各种ctDNA测试的成本效益.
综合关于ctDNA与已建立的查方式相比的经济价值的发现.

主要方法:

在多个数据库中,根据PRISMA指南进行了全面的文献搜索.
包括专注于健康经济分析的研究:成本效益,成本效益,成本效益和成本后果.
使用CHEERS 2022标准评估了所包含报告的质量,所有报告都被评为"非常好".

主要成果:

十八项研究评估了四个ctDNA测试 (EBV-DNA,cf-DNA,mSEPT9,mt-sDNA) 的鼻,乳腺和结肠直肠癌.
在27.78%的研究中,ctDNA在结直肠癌查中被发现具有成本效益,特别是 mt-sDNA的吸收率更高.
大多数研究 (72.22%) 表明ctDNA与NPC,BC和CRC查的传统方法相比没有成本效益.

结论:

与传统的癌症查方法相比,大多数ctDNA测试的成本效益并不高.
具体的情景,如mt-sDNA或mSEPT9相比CTC的更高吸收率,显示出潜在的成本效益.
需要进一步的研究和特定背景的分析,才能充分理解ctDNA查的经济影响.

关键词:

癌症癌症癌症癌症癌症在循环中的瘤DNA.查检查查检查查检查查检查系统性审查系统性审查

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