鼻腔封闭是否是HHT中严重耐火性表症的有效治疗方法? 一个范围审查和叙事综合
R Bickerton1, R Gera1, T Ross2
1Department of Ear, Nose and Throat Surgery, Imperial College Healthcare Trust, London, United Kingdom.
Rhinology
|February 5, 2025
概括
鼻子关闭手术有效地减少严重的表 (鼻血) 并改善遗传性出血端膜切除症 (HHT) 患者的生活质量. 这种程序为质疑HHT案件提供了一个有价值的选择.
科学领域:
- 医学研究 医学研究
- 外科手术的结果
- 遗传性疾病 遗传性疾病
背景情况:
- 遗传性出血端膜切除症 (HHT) 导致严重的,反复复发的表膜切除 (鼻血),带来了重大管理挑战.
- 鼻腔闭塞是对耐火性HHT病例的新兴治疗方法,但其结果需要进一步调查.
研究的目的:
- 系统地审查和评估与HHT相关的鼻腔封闭的疗效和安全性.
- 巩固有关HHT患者鼻腔闭塞结果的现有证据.
主要方法:
- 30年来对主要数据库 (Cochrane,EMBASE,PubMed) 和非索引出版物的系统文献搜索.
- 数据提取和偏见评估由两位独立审稿人进行.
- 由于研究异质性而导致的发现的叙述综合.
主要成果:
- 分析了10项涉及192名接受鼻塞治疗的患者的研究.
- 鼻腔封闭显示改善了生命质量,并在术后减少了表症的严重程度.
- 部分脱色是一种常见的并发症,通常通过修复手术成功管理.
结论:
- 鼻腔闭塞是一种有效的治疗方法,可以减少表症的严重程度,并提高重度,耐火性HHT的生活质量.
- 这种手术对于复杂的HHT病例来说是一个有价值的治疗选择.
- 研究结论受到结果测量异质性的限制;这是迄今为止最大的聚合数据库.
相关概念视频
Epistaxis
119
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
119
Tracheostomy Decannulation
91
Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
91
Angle Closure Glaucoma: Treatment
432
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
432
Suctioning the Nasopharyngeal Airway
243
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
243


