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肌酸补充剂可以缓解多克索鲁比诱导的骨肌肉功能障碍,但不能缓解心脏毒性
Paola Sanches Cella1, Ricardo Luís Nascimento de Matos2, Poliana Camila Marinello3
1Department of Physical Education, State University of Londrina, Londrina, PR, Brazil.
Nutrition and cancer
|February 5, 2025
概括
肌酸补充保护了骨肌肉免受多克索鲁比诱导的毒性和缩. 然而,它并没有为心肌提供对多克索鲁比的保护.
科学领域:
- 生物化学 生物化学
- 肌肉生理学 肌肉生理学
- 毒理学 毒理学 毒理学
背景情况:
- doxorubicin 是一种强大的化疗剂,具有已知的心脏毒性和肌肉毒性副作用.
- 肌酸因其在能量代谢中的作用而闻名,并且已经证明它对肌肉功能障碍有保护作用.
- 克reatine对多克索鲁比诱导的心脏和骨肌肉毒性的特定保护能力尚未得到充分证实.
研究的目的:
- 调查肌酸补充剂对多克索鲁比诱导的心脏毒性和骨肌肉毒性的潜在保护作用.
- 为了评估肌酸对氧化应激和炎症标志物的影响,作为对多克索鲁比治疗的反应.
主要方法:
- 20只雄性C57BL/6J小鼠被分为三个组:对照组,用多克索鲁比 (Dox) 治疗的小鼠,以及用多克索鲁比加肌 (DoxCr) 治疗的小鼠.
- doxorubicin 每周一次,而 DoxCr 组同时接受肌酸补充剂.
- 评估了骨肌缩,肌肉强度,心脏质量,心肌细胞直径,氧化应激标志物 (MDA,GSH/GSSG比率) 和IL-6水平.
主要成果:
- 德克索鲁比诱导了扩展体长和长肌肉的显著骨肌缩,肌肉力量降低,氧化应激和IL-6水平增加.
- 心脏毒性的证据是心脏质量减少,心肌细胞直径减少和IL-6升高.
- 肌酸补充剂减轻了多克索鲁比诱导的氧化应激,并预防了骨肌肉缩和力量丧失,但没有保护心肌.
结论:
- 肌酸补充剂对骨肌肉产生显著的保护作用,防止多克索鲁比诱导的毒性,包括缩和力量减弱.
- 肌酸似乎无法保护心肌免受多克索鲁比的毒性影响.
- 需要进一步的研究,以了解肌酸对骨肌肉和心脏肌肉的差异性影响,在化疗诱导毒性的背景下.
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