从Stryphnodendron adstringens (Mart.) 的树皮,茎和叶子中提取的乙醇提取物中的生物活性科维尔 (Coville) 是一个城市

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T C Reis¹, L F de Paiva², V H M Santos²

¹Universidade Estadual Paulista "Júlio de Mesquita Filho - UNESP, Faculdade de Ciências Farmacêuticas, Departamento de Análises Clínicas, Araraquara, SP, Brasil.

Brazilian journal of biology = Revista brasleira de biologia

|February 5, 2025

概括

斯特里夫诺登德朗 (Stryphnodendron adstringens) 或巴巴蒂蒙 (barbatimão) 具有强大的抗菌和抗真菌特性,特别是在抗结核菌和白菌 (Candida albicans) 的情况下. 这种巴西植物提取物具有高抗氧化能力和低细胞毒性,使其成为新药开发的有希望来源.

科学领域:

民族植物学和植物化学.
药理学和药物发现

背景情况:

斯特里夫诺登德龙 (Stryphnodendron adstringens) 是一种植物,原产于巴西的塞拉多生物群,属于花科.
传统用途表明其潜在的药用特性,需要对其生物活性进行科学验证.

研究的目的:

评估从Stryphnodendron adstringens树皮,叶子和茎中提取的原始乙醇提取物的生物活性.
量化关键的植物化学物质,如日,和黄,并评估抗氧化,抗菌,抗真菌,抗寄生虫和细胞毒性作用.

主要方法:

使用水乙醇溶剂提取植物材料 (树皮,叶子,茎).
使用色度和Folin-Ciocalteu方法进行定性和定量植物化学分析 (素,类,黄类).
在体外分析:DPPH用于抗氧化活性,磁盘扩散用于抗菌/抗真菌,MTT用于抗寄生虫和细胞毒性.

主要成果:

提取物显示出对酵母 (Candida albicans) 和细菌 (Mycobacterium tuberculosis) 的显著有效性.
观察到高抗氧化能力 (92%以上的叶子和茎提取物) 和低细胞毒性 (CC50 > 300μg/mL).
没有检测到针对Leishmania amazonensis的显著抗寄生虫活性.

结论:

斯特里夫诺登德龙 (Stryphnodendron adstringens) 是一种有价值的化合物来源,具有显著的抗菌和抗真菌特性.
植物的高抗氧化能力和低细胞毒性支持其开发抗传染病和氧化应激相关疾病药物的潜力.
对隔离活性化合物的进一步研究可能会导致新的治疗剂.

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