估计的小密度低密度脂蛋白胆固醇 (sdLDL-C) 与动脉样硬化心血管疾病风险之间的关联
Shutang Zhang1, Jinjie Du1, Peng Wang1
1Chongqing University Fuling Hospital, Chongqing Clinical Research Center for Geriatric Diseases - Geriatrics, Chongqing - China.
Arquivos brasileiros de cardiologia
|February 5, 2025
概括
估计小密度低密度脂蛋白胆固醇 (sdLDL-C) 的新公式可以预测动脉样硬化心血管疾病 (ASCVD) 风险. 估计高的sdLDL-C (EsdLDL-C) 水平与更高的ASCVD风险有关,这表明它在风险评估中的有用性.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 公共卫生 公共卫生
背景情况:
- 动脉样性心血管疾病 (ASCVD) 风险是全球主要的健康问题.
- 小,密集,低密度脂蛋白胆固醇 (sdLDL-C) 是ASCVD的一个重要风险因素.
- 在常规的临床实践中,精确测量sdLDL-C可能具有挑战性.
研究的目的:
- 引入和验证使用标准脂质面板结果估计sdLDL-C (EsdLDL-C) 的新型公式.
- 调查EsdLDL-C与ASCVD风险之间的关联.
- 探索EsdLDL-C,高血压和ASCVD风险之间的潜在相互作用.
主要方法:
- 一项对12192名来自韩国国家健康和营养检查调查 (KNHANES) (2010-2020) 的参与者的横截面研究.
- 使用以下公式计算EsdLDL-C:EsdLDL-C = LDL-C - [1.43 × LDL-C - (0.14 × (ln (TG) × LDL-C)) - 8.99].使用该公式计算EsdLDL-C.
- 进行了后勤回归分析和子组分析 (年龄,BMI,高血压,糖尿病),以评估ASCVD风险相关性.
主要成果:
- 10.16%的参与者患有ASCVD.
- 升高的EsdLDL-C水平与ASCVD风险增加显著相关 (OR=1.33;95%CI,1.06-1.66).
- 在高血压和EsdLDL-C (Pinteraction=0.001) 或非HDL-C (Pinteraction=0.015) 之间观察到关于ASCVD风险的显著相互作用.
结论:
- 拟议的公式提供了sdLDL-C.的可靠估计.
- 升高的EsdLDL-C是ASCVD风险的重要预测因素.
- 对于ASCVD风险分层,EsdLDL-C可以作为直接sdLDL-C测量的一个有价值的替代方案.
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