相关实验视频

Updated: May 29, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

帕金森病的运动症状变化:对个性化试验结果的影响?

Jules Janssen Daalen^1,2, Maudy van der Heiden^1,2, Marjan Meinders²

¹Radboud University Medical Center, Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Center of Expertise for Parkinson and Movement Disorders, Nijmegen, The Netherlands.

Movement disorders : official journal of the Movement Disorder Society

|February 5, 2025

概括

帕金森病 (PD) 的日常运动症状波动往往超过MDS-UPDRS第三部分尺度的临床重要差异最小值 (MCID). 这种变化可能会影响短期临床试验结果.

科学领域:

神经学神经学
运动障碍运动障碍
临床试验临床试验

背景情况:

运动障碍学会统一帕金森病评分表 (MDS-UPDRS) 第三部分是评估帕金森病 (PD) 运动症状的标准.
在短期或交叉临床试验中,PD运动症状的每日显著波动可能会降低MDS-UPDRS Part III的灵敏度.

研究的目的:

为了确定帕金森病运动症状的日复一日变异性是否超过MDS-UPDRS第三部分的临床重要差异最小值 (MCID).

主要方法:

20名患有帕金森病的参与者 (Hoehn & Yahr 1.5-3阶段) 完成了每周10次停药评估.
一个评估员每周在同一天早上进行所有评估.
研究了导致症状日复一日变化的因素.

主要成果:

运动症状变异性经常超过MCID,无论是症状恶化还是改善.
目前的心理压力或疲劳与症状严重程度增加之间没有发现显著的相关性.
上周的体力活动和睡眠质量与运动症状得分无关.

结论:

日复一日的症状变化可能会影响临床试验中MDS-UPDRS Part III评分的解释,特别是那些持续时间短或样本规模较小的临床试验.
使用可穿戴传感器的持续监测可以在研究环境中提供更精确和可靠的对帕金森病运动症状的评估.

关键词:

帕金森病的疾病.结果评估结果评估结果症状严重程度症状严重程度试验方法论试验方法论

更多相关视频

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

相关概念视频

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.