在患有慢性精神分裂症的中国患者中,童年创伤,临床症状和认知功能之间的性别差异
ZhaoXuan Shang1, ChunQing Fang1, GuoShuai Luo2
1Department of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
Social psychiatry and psychiatric epidemiology
|February 5, 2025
概括
童年创伤对男性和女性的精神分裂症症状的影响不同. 了解这些性别特异性影响对于开发针对性治疗慢性精神分裂症患者至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 童年创伤是发展精神疾病的重要危险因素.
- 精神分裂症是一种复杂的精神障碍,具有不同的临床表现.
- 人们越来越认识到精神分裂症病理生理学和治疗反应中的性别差异.
研究的目的:
- 调查儿童创伤,临床症状和慢性精神分裂症中国患者的认知功能之间的特定性别关联.
- 根据性别识别创伤相关症状的不同模式.
- 为制定针对精神分裂症量身定制的治疗策略提供信息.
主要方法:
- 评估了601名被诊断患有慢性精神分裂症的患者队列.
- 儿童创伤使用童年创伤问卷-简短表格 (CTQ-SF) 进行评估.
- 临床症状和认知功能分别使用阳性和阴性综合征尺度 (PANSS) 和神经心理状态评估重复电池 (RBANS) 进行测量. 使用相关性和回归分析来检查关系,控制性别.
主要成果:
- 在童年创伤的患病率上没有观察到显著的性别差异.
- 在男性患者中,身体疏忽与积极症状 (PANSS) 的增加以及身体虐待与较差的视觉空间结构相关.
- 在女性患者中,情绪性忽视与增加的积极和兴奋症状 (PANSS) 相关,情绪性虐待增加了抑郁症状,性虐待降低了语言能力,身体性忽视导致记忆缺陷 (即时和延迟).
结论:
- 该研究揭示了不同的性别特异性途径,通过这些途径,童年创伤会影响慢性精神分裂症的临床症状.
- 这些发现强调了在评估和治疗有创伤史的精神分裂症患者时考虑性别的重要性.
- 建议采取量身定制的,以性别为基础的干预措施,以有效地管理症状概况并改善结果.
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