建立混合老鼠多样性计划:用于剖析复杂特征的资源.
M R Dwinell1, A Takizawa2, M Tutaj2
1Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA. mrdwinel@mcw.edu.
概括
杂交大鼠多样性小组 (HRDP) 为研究复杂疾病提供了各种同系大鼠菌株的宝贵资源. 该小组提供了基因组和表型数据,以推进系统遗传学研究和药物发现.
科学领域:
- 遗传学 是一个遗传学.
- 动物模型 动物模型
- 系统生物学 系统生物学
背景情况:
- 在疾病机制,行为和药物开发方面的可重复性研究中,同系大鼠菌株至关重要.
- 在大鼠模型中的基因背景控制可以实现精确的表型.
- 对系统遗传学的多样化遗传资源的需求已经得到了很好的证实.
研究的目的:
- 建立混合老鼠多样性小组 (HRDP) 作为系统遗传学的综合资源.
- 为了最大限度地提高同系大鼠菌株之间的遗传多样性,以进行增强的特征关联研究.
- 为科学界提供综合的基因组,生理和行为数据.
主要方法:
- 杂交鼠群多样性小组 (HRDP) 的开发,包括96-98种杂交鼠株.
- 通过胚胎复苏和繁殖建立繁殖殖民地.
- 全基因组测序以实现对所有菌株的30倍覆盖.
主要成果:
- 创建一组基因多样化的同系大鼠菌株组.
- 成功建立和分配HRDP殖民地.
- 生成全面的基因组和表型数据.
结论:
- 人力资源发展计划是识别与复杂特征相关的遗传基因位置的强大资源.
- 人权发展计划促进了了解疾病机制和药物发现的进步.
- 通过大鼠基因组数据库访问的综合数据促进了协作研究.
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