在亚洲人口中,生活方式因素,生理条件和表观遗传年龄加速之间的关联
Yu-Ru Wu1, Wan-Yu Lin2,3,4
1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Room 501, No. 17, Xu-Zhou Road, Taipei, 100, Taiwan.
Biogerontology
|February 5, 2025
概括
生活方式和生理因素显著影响亚洲成年人的表观遗传衰老加速 (EAA). 吸烟,BMI和HbA1c与更快的生物衰老有关,而HDL-C和血红蛋白表明衰老速度较慢.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 基于DNA甲基化 (DNAm) 的表观遗传钟估计了生物年龄.
- 在亚洲人群中,生活方式,生理因素和表观遗传衰老加速 (EAA) 之间的关联尚未得到充分理解.
研究的目的:
- 探索生活方式因素,生理条件和台湾队列中的各种表观遗传标记之间的关系.
- 确定表观遗传年龄加速和减速的关键预测因素.
主要方法:
- 利用了2474名台湾生物库参与者 (年龄在30-70岁) 的数据.
- 进行了部分相关性分析和模型选择 (Akaike信息标准),以确定29个因素和表观遗传标记之间的显著关联.
- 评估了多个EAA标志物,包括HannumEAA,IEAA,PhenoEAA,GrimEAA,以及基于DNAm的吸烟包年.
主要成果:
- 29个因素与至少一个表观遗传标志物显著相关.
- 最好的解释是15个因素 (包括性别,BMI,WHR,吸烟,HbA1c,HDL-C,肌,尿酸,GT,血红蛋白和细胞类型比例),占其变化的44.7%.
- 吸烟,升高的HbA1c,BMI,WHR,GGT和尿酸与EAA增加有关,而较高的HDL-C和血红蛋白与表观遗传衰老 (EAD) 相关.
结论:
- 生活方式和生理因素在研究的亚洲人口的表观遗传衰老中发挥着重要作用.
- 确定了与加速和减缓生物衰老相关的特定生物标志物和生活方式选择.
- 研究结果提供了对影响生物衰老和健康的可修改因素的见解.
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