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在长期COVID中慢性自主症状负担:后续队列研究

Ella F Eastin¹, Jannika V Machnik¹, Lauren E Stiles¹

¹Department of Neurology and Neurological Sciences, Stanford University, 213 Quarry Road, Stanford, CA, 94304, USA.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society

|February 5, 2025

概括

大多数长期COVID患者经历慢性自主功能障碍,影响生活和工作质量. 静止性心力衰竭综合征 (POTS) 是一个常见的诊断,女性性别和关节高移动性是危险因素.

科学领域:

神经学神经学
心脏病学心脏病学
传染性疾病传染性疾病

背景情况:

长期COVID (LC) 经常表现为衰弱的自主功能障碍.
有限的研究量化了COVID-19后自主问题的慢性和严重程度.

研究的目的:

评估长期COVID队列中自主功能障碍的频率,严重程度和持续时间.
研究自主功能障碍对生活质量和功能能力的影响.
确定自主诊断的风险因素,包括姿势性心跳动综合征 (POTS),并评估治疗疗效.

主要方法:

利用了526名长期COVID患者成年人的国际在线队列.
对LC症状,自主负担,生活质量和风险因素进行了经过验证的调查.
包括对参与者的子集进行活跃的站立测试.
采用多变量逻辑回归来确定自主功能障碍和POTS的预测因素.

主要成果:

71.9%的参与者表现出中度至严重的自主功能障碍 (COMPASS-31评分≥20).
症状持续时间中位数为36个月;37.5%的人无法工作或学习.
在40.5%的自主功能障碍患者中 (33%的总队列中) 新确诊的姿势性心跳动综合征 (POTS).
女性性别和关节超运动与自主功能障碍风险增加有关.

结论:

慢性中度至严重的自主功能障碍在长期COVID患者中很普遍.
自主功能障碍与生活质量下降和功能障碍显著相关.
在COVID-19感染后,POTS是最常见的自主诊断.

关键词:

自主性的功能障碍.这种自主性很差.长时间的COVID.在COVID-19 (PASC) 的后急性病例中.姿势静止性心动减速综合征 (POTS)

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