由Bifidobacterium adolescentis衍生出的尼古丁酸改善宿主骨肌的线粒体功能,以改善肉症
Zeng Zhang1, Quan Guo1, Zhihan Yang1
1School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, Haikou 570228, Hainan, China.
Cell reports
|February 5, 2025
概括
青少年双杆菌 (Bifidobacterium adolescentis) 的枯竭与肉症有关. 补充其代谢物尼古丁酸,可以通过提高NAD+水平和抑制肌肉缩来改善肌肉质量和功能.
科学领域:
- 微生物学 微生物学
- 老年学是指老年学的学科.
- 肌肉生理学 肌肉生理学
背景情况:
- 老年人肌肉损失的一种疾病 - - 萨科佩尼 - - 显著影响健康和生存.
- 人们越来越认识到肠道微生物群在肌肉健康中的作用,但机制仍然不清楚.
研究的目的:
- 为了研究肠道细菌和肉症之间的联系.
- 为了确定可能影响肌肉健康的特定细菌代谢物.
主要方法:
- 快枪元基因组学和代谢学被用来分析来自有和没有肉类的个体的样本.
- 这些发现在老老鼠模型中得到了验证.
- 机械学研究探讨了尼古丁酸对肌肉细胞的影响.
主要成果:
- 发现Bifidobacterium adolescentis在患有肉类的个体中已经枯竭.
- 由B. adolescentis产生的尼古丁酸与改善的肌肉质量和功能相关.
- 尼古丁酸恢复了肌肉的尼古丁胺胺腺因二核酸 (NAD+) 水平,抑制了FoxO3/Atrogin-1/Murf-1通路,并促进了卫星细胞的增殖.
- 通过尼古丁酸激活NAD+增强了SIRT1/PGC-1α通路,促进了线粒体生物发生和氧化代谢.
结论:
- 青少年双杆菌的缺乏可能会导致肉症.
- 尼古丁酸是从B. adolescentis中衍生出来的,它显示出作为治疗萨尔科佩尼亚的治疗剂的潜力.
- 针对肠道微生物组及其代谢物提供了一种新的策略,用于打击与年龄相关的肌肉衰退.
关键词:
青少年的双杆菌是什么CP:新陈代谢过程中的新陈代谢.CP: 微生物学 微生物学它们是NAD+NAD+NAD.我们的肠道微生物组.线粒体的生物生成 线粒体的生物生成多种主题的多种主题.尼古丁酸是一种尼古丁酸.这种类型的麻症是sarcopenia.这是骨肌肉的骨架肌肉.更多相关视频
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