在临床研究和实践中对一氧化碳暴露的诊断:范围审查
Phil Moss1, Natasha Matthews1, Rosalie McDonald1
1St Georges' Emergency Department Clinical Research Group, Emergency Department, St Georges' Hospital, London, United Kingdom.
PloS one
|February 5, 2025
概括
这次审查确定了诊断无意中毒一氧化碳的四种方法. 标准化诊断碳氧血红蛋白水平对于准确的患者评估和治疗至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 无意的,与火灾无关的一氧化碳 (CO) 暴露对公众健康构成重大风险.
- 准确及时诊断对于有效的患者管理和预防长期健康后果至关重要.
- 目前的诊断方法和CO中毒的确定的门缺乏标准化.
研究的目的:
- 进行范围审查,以确定用于诊断非故意,非火灾相关一氧化碳暴露的方法.
- 确定用于确定一氧化碳中毒的诊断水平.
主要方法:
- 对在线数据库和灰色文献进行了全面的范围审查.
- 搜索涵盖了1946年至2023年的出版物,确定了80篇报告一氧化碳水平的论文.
- 包括的文献包括71个研究研究和9个临床指南.
主要成果:
- 确定了评估CO暴露的四种主要方法:血液中碳氧血红蛋白分析,CO氧量测 (SpO2),过期CO测量和环境CO采样.
- 血液中碳氧血红蛋白分析是主要的方法,在60.0%的审查论文中使用.
- 在67.5%的论文中报告了诊断性碳氧血红蛋白水平,范围从2%到15%,其中32.5%的调整为吸烟状态.
结论:
- 对CO暴露的确定的诊断方法各不相同,并在不同的临床环境中应用.
- 诊断值的显著变化阻碍了CO中毒的准确和一致的诊断.
- 诊断CO水平的标准化迫切需要,以提高诊断准确性和患者护理.
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