瓦拉西克洛维尔与阿西克洛维尔治疗疹简单病毒抑制新生儿感染后的新生儿感染
Haley A Olkiewicz1, Michelle L Mitchell2, Katie M Ray3
1Children's Wisconsin, Milwaukee, Wisconsin, holkiewicz@childrenswi.org.
WMJ : official publication of the State Medical Society of Wisconsin
|February 5, 2025
概括
瓦拉克洛维可能是阿西克洛维尔的有效替代品,用于抑制新生儿简单疹病毒 (HSV) 感染,显示出类似的复发率. 这种抗病毒药物提供了潜在的好处,比如为患有HSV的婴儿提供更少的剂量.
科学领域:
- 新生儿医学 新生儿医学
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的数据存在于valcyclovir对于新生儿简单疹病毒 (HSV) 抑制.
- 事证据表明潜在的疗效.
研究的目的:
- 为了比较新生儿HSV抑制的瓦拉西克洛维尔和阿西克洛维尔之间的HSV复发率.
- 为了评估瓦拉基克洛维尔与阿西克洛维尔在婴儿中的疗效.
主要方法:
- 婴儿 (<6周大) 呈阳性HSVPCR的回顾性队列研究.
- 对接受口服阿西克洛维尔或瓦拉西克洛维尔的患者的人口统计,剂量和复发率的分析.
主要成果:
- 六名患者接受了阿西克洛维尔,13名患者接受了瓦拉西克洛维尔.
- 简单疹病毒复发率在阿西克洛维尔和瓦拉西克洛维尔组之间是相似的.
结论:
- 瓦拉克洛维尔为新生儿HSV抑制提供了阿西克洛维尔的潜在替代品.
- 瓦拉赛克洛维尔可能会改善由于不太频繁的剂量而导致的遵守.
- 需要进行更多的大型研究,以证实瓦拉西克洛维尔在新生儿中的疗效.
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