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基托桑化涂层和非离子表面活性剂修饰的尼奥索姆:一种更好的方式来口服塞马格卢提德的管理

Ben Wang¹, Zhengxing Su^2,3, Meiyan Kuang¹

¹School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 401135, People's Republic of China.

Biomedical materials (Bristol, England)

|February 5, 2025

概括

新的口服输送系统CS.HCL-NSPEs-NIO增强了类型2糖尿病治疗的血红蛋白吸收. 这种方法可以改善血糖控制,促进减肥,没有观察到毒性.

科学领域:

药理学药理学是指药理学的学科.
药物输送系统药物输送系统
内分泌学在内分泌学.

背景情况:

糖尿病是一种日益严重的全球健康问题,预计到2030年将影响6.43亿人.
作为GLP-1模拟物,塞马格卢提德有效地控制血糖,并降低2型糖尿病中低血糖的风险.
口服塞马格卢提德面临的挑战是吸收效率.

研究的目的:

开发和评估酸盐化物涂层和非离子表面活性剂修饰的尼奥体 (CS.HCL-NSPEs-NIO) 用于口服半谷类胺的输送.
为了增强塞马格卢提德的肠道吸收和低血糖疗效.

主要方法:

在CS.HCL-NSPEs-NIO.IO中封装塞马格卢提德.
评估肠道细胞结口的透和药物吸收.
在体内进行胃肠道分布研究.
在db/db小鼠中评估降血糖效应和体重变化.
对主要器官的毒性评估.

主要成果:

CS.HCL-NSPEs-NIO证明了肠内皮的有效透,增强了半谷氨酸的吸收.
体在肠道中停留了4个多小时,使得葡萄糖持续调节.
在接受治疗的小鼠中观察到血糖水平和体重的显著降低.
在主要器官中没有检测到不良毒性.

结论:

CS.HCL-NSPEs-NIO是一个有前途的口服输送系统,用于semaglutide.
这种新的配方增强了塞马格卢提德的低血糖作用,为2型糖尿病提供了潜在的新疗法策略.

关键词:

糖尿病糖尿病患者糖尿病患者在口服交付口服交付.透增强剂是一种透增强剂.塞马格卢提德 (semaglutide) 是一种可怕的药物.

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