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在患有严重抑郁症的患者中,受COVID-19影响的多式联络成像特征显著

Taipeng Sun¹, Chenguang Jiang², Yubo Zhang²

¹Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China; Department of Medical Psychology, Huai'an No.3 People's Hospital, Huaian, 223001, Jiangsu, China.

Journal of psychiatric research

|February 5, 2025

概括

在健康个体中,COVID-19感染会损害白质 (WM),并且在严重抑郁症 (MDD) 患者中会恶化现有的WM损伤. 在这两组中,白质似乎比灰质更容易受到COVID-19的感染.

科学领域:

神经科学是一个神经科学.
传染性疾病传染性疾病
精神病学是一个精神病学.

背景情况:

众所周知,COVID-19会导致大脑的结构和功能变化.
关于COVID-19对患有严重抑郁症 (MDD) 个体的具体影响的数据有限.

研究的目的:

研究COVID-19感染对MDD患者的大脑结构和功能的影响,与健康对照 (HCs) 相比.
在MDD患者和HC患者中识别受COVID-19影响的特定大脑区域和白质道.

主要方法:

利用MRI扫描,包括T1加权成像,扩散张力成像 (DTI) 和静止状态功能性MRI.
将四组进行比较:MDD患者在COVID-19之前 (n=165) 和之后 (n=70),HC患者在COVID-19之前 (n=108) 和之后 (n=57).
在2022年1月至2023年8月期间收集的数据.

主要成果:

COVID-19主要导致白质 (WM) 与灰质 (GM) 的结构变化.
在MDD患者中受到影响的特定WM通道包括上方纵向囊,小,以及环-环回.
在GM和WM中观察到功能性变化,特别是在补充运动区域,左角环,杏仁体,副海马环和各种WM区域.

结论:

在健康个体中,COVID-19感染会导致显著的微观结构性WM损伤.
在MDD患者中,COVID-19加剧了先前存在的白质微观结构损伤.
在MDD患者和健康对照中,白质似乎比灰质更容易受到COVID-19相关的损伤.

关键词:

大脑功能大脑功能大脑结构大脑结构在 COVID-19 疫情中,灰色物质是一种灰色物质.大型抑郁症主要是抑郁症.白质是白质的组成部分.

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