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探索多环染料在有氧生物降解过程中的转化和毒性的渐进变化

Zhengkun Tang¹, Chenye Xu¹, Chensi Shen¹

¹College of Environmental Science and Engineering, Donghua University, Textile Pollution Controlling Engineering Center of Ministry of Environmental Protection, Shanghai 201620, China.

Journal of hazardous materials

|February 5, 2025

概括

研究了多环色素 (PD) 和前体的生物降解,显示了快速降解,但副产品的毒性增加. 这项研究提供了关于管理废水中新出现的污染物的环境风险的见解.

科学领域:

环境化学环境化学
生物技术是生物技术.
毒理学毒理学毒理学

背景情况:

染料生物降解性和毒性的结构-活性模型受到由于副产品形成而导致的降解过程中的动态变化所限制.
多环染料及其前体是常见的环境污染物,需要进行评估.
了解生物降解动力学和毒性演变对于环境风险管理至关重要.

研究的目的:

研究常见的多环染料及其前体的有氧生物降解动力学和毒性演变.
分析转化产品对整体毒性的影响.
开发一种综合方法来评估新出现的污染物的环境风险.

主要方法:

结合体内和体内的方法被用于研究生物降解动力学.
分子动力学模拟量化了化合物和氧化降解酶之间的结合能.
开发了一种使用抑制/TOC (I/TOC) 比率的新毒性评估方法,并通过HPLC-TOF-MS和T.E.S.T.进行验证. 预测. 预测. 预测. 预测.

主要成果:

大多数化合物在6-8小时内迅速降解,被替代的甲显示了最高的降解率 (kmax = 0.278 h-1).
较强的与氧化还原酶的结合相互作用与较低的降解率相关.
大多数化合物的生物降解后毒性增加,三甲染料显示出明显更高的I/TOC值 (p <0.05).
确定了18种主要的转化产品,预计比母化合物更有毒.

结论:

结合生物降解动力学,分子模拟和毒性演变的综合方法为环境风险评估提供了关键的见解.
PDs的生物降解可能导致更有毒的中间体的形成,需要在废水处理过程中进行谨慎的管理.
新的I/TOC比为评估生物降解过程中的毒性变化提供了有价值的工具.

关键词:

对水生有毒性的水生毒性生物降解性生物降解性抑制/TOC 的抑制.分子动力学分子动力学多环形染料多环形染料

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