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Updated: May 29, 2025

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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通过ROS PAMPs介导的细胞外HMGB1自我关联及其二元化增强了促炎信号传递

Man Sup Kwak1, Myeonggil Han2, Yong Joon Lee3

  • 1Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, South Korea; Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, 03722, South Korea.

Redox biology
|February 5, 2025
PubMed
概括

细胞外高流动性组盒子1 (HMGB1) 蛋白通过Cys106形成二硫化物结合的二次体,显著增强促炎信号传递. 这种由PAMPs和H2O2触发的二分化,增加了与TLR2/4的结合和细胞因子的产生.

关键词:
变质化变质化是指变质化的过程.这就是HMGB1的特点.炎症 炎症是一种炎症.有反应性氧物种的反应性氧物种.

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