辅酶Q10和L-卡尼丁对抗抑郁药诱导的线粒体功能障碍和胚胎中的原性有保护作用
Hsun-Hua Lee1, Hsiang-Cheng Chi2, Kent Lin3
1Department of Neurology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Dizziness and Balance Disorder Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|February 5, 2025
概括
西和阿尔普拉佐拉姆会引起原性作用和线粒体损伤. 同酶Q10和L-卡尼丁显示出对这些药物诱导的不良反应的保护潜力.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 发展生物学 发展生物学
- 线粒体医学 线粒体医学
背景情况:
- 素 (FXT) 和阿尔普拉佐拉姆 (APZ) 是广泛用于治疗精神疾病的药物.
- 它们对线粒体功能的不良影响,包括氧化酸化和膜透性,尚未得到充分证实.
- 了解这些影响对于患者安全和治疗发展至关重要.
研究的目的:
- 在小胚胎模型中研究FXT和APZ的致性作用.
- 探索辅酶Q10 (CoQ10) 和L-卡尼丁 (CNT) 对药物诱导的线粒体功能障碍的保护潜力.
- 阐明产性潜在机制,重点关注脂质代谢和氧化应激.
主要方法:
- 使用了一个小胚胎模型 (汉堡 - 汉密尔顿第10阶段,第1.5天).
- 给药FXT (10μM) 和APZ (1μM) 有或没有CoQ10 (2μM) 和CNT.
- 评估的致病率,脂质肌病,基因表达 (ACC,CPT1),氧化应激标志物 (SOD,H2O2,NO,GSH),线粒体超结构和ATP产生.
主要成果:
- FXT和APZ诱导了高原性率 (分别为53%和80%),主要是脂质肌病.
- 药物导致脂质过氧化受损,活性氧物种 (ROS) 增加和线粒体损伤,导致ATP减少.
- 同时服用辅酶Q10和CNT显著改善了产性和死亡率,并减少了氧化应激.
结论:
- 通过氧化应激和改变脂质代谢,FXT和APZ诱导显著的原性效应和线粒体功能障碍.
- CoQ10和CNT显示出对这些不良结果的显著保护作用.
- 辅酶Q10和CNT是有希望的营养补充剂,可以缓解药物诱导的线粒体损伤和氧化失衡.
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