童年不良经历会影响莱普丁的长度变化,但不影响adiponectin
Sara Matovic1, Christoph Rummel, Elena Neumann
1From Concordia University (Matovic, McGrath, Gouin), Montreal, Canada; Institute of Veterinary Physiology and Biochemistry, Justus Liebig University Giessen (Rummel), Giessen, Germany; Center for Mind, Brain and Behavior (CMMB), University of Marburg and Justus Liebig University Giessen (Rummel, Neumann), Marburg and Giessen, Germany; and Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University of Giessen (Neumann), Bad Nauheim, Germany.
Biopsychosocial science and medicine
|February 5, 2025
概括
童年不良经历 (ACE) 与母亲随着时间的推移增加叶素水平有关,从而增加心脏代谢风险. 这种效应部分由中央脂肪度介导,突出显示了早期生活压力与以后健康结果之间的关键联系.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 心理神经免疫学 心理神经免疫学
背景情况:
- 儿童不良经历 (ACE) 与肥胖和心脏代谢疾病风险增加有关.
- 勒普丁和阿迪波涅丁等阿迪波金在代谢调节中起着关键作用,它们的不平衡与肥胖有关.
- 阿迪波涅丁/莱普丁比率可能表明脂肪组织功能失调.
研究的目的:
- 研究ACEs对莱普丁,阿迪波涅克丁和阿迪波涅克丁/莱普丁比率的纵向影响.
- 检查当前慢性压力和肥胖对这些关系的影响.
- 探索肥胖在ACE和adipokine变化之间的关联中的潜在调解作用.
主要方法:
- 对192名中年母亲进行了长度研究,这些母亲患有各种慢性护理压力.
- 在30个月的三个时间点测量阿迪波金 (莱普丁,阿迪波内克丁) 和脂肪度.
- 使用童年创伤问卷对ACE的回顾性评估.
主要成果:
- 在研究期间,丁和阿迪波内克的水平都增加了.
- 随着时间的推移,较高的ACE暴露与较大的勒激素增加相关.
- 增加的腰围部分介导了ACE和瘦素水平增加之间的关联.
结论:
- ACE可能会增加中年母亲对心脏代谢风险的脆弱性.
- 由ACEs影响的瘦素和中央脂肪度的长度变化可能是这种风险增加的基础.
- 当前的护理压力没有显著影响阿迪波金水平或与ACEs效应相互作用.
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