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Updated: Jun 13, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay

Published on: September 27, 2024

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杜基因酶USP9X控制中枢神经系统血管形成和屏障维护的Wnt信号

Yi Lei1, Jiandong Hu1, Jiyun Zhao1

  • 1Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Developmental cell
|February 5, 2025
PubMed
概括

乌比基特异性酶9X结合 (USP9X) 对大脑内皮细胞至关重要,通过Wnt信号调节中枢神经系统血管化和屏障功能. 失去USP9X会损害这些过程,恶化中枢神经系统疾病模型.

关键词:
没有信号发送.血脑屏障是什么意思血液与视网膜屏障的形成没有除酶的酶.血管化的血管化.

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