在现实世界中治疗神经血管与年龄相关的黄斑退化症的退出策略:妄想?
Michael Eastline1, Sadiq Said1,2, Martina Monika Bosch1,2
1Eye Clinic Wettingen, Switzerland.
Klinische Monatsblatter fur Augenheilkunde
|February 5, 2025
概括
在对新血管与年龄相关的黄斑变性 (nAMD) 的现实研究中,只有22.6%的患者通过aflibercept治疗完成治疗. 在结束治疗的患者中,超过四分之一的患者出现了疾病复发.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 是导致视力丧失的主要原因.
- 阿弗利伯塞普特是一种常见的nAMD治疗方法,通常通过治疗和扩展 (T&E) 方案进行.
- 在现实环境中研究T&E方案的长期结果对于优化患者护理至关重要.
研究的目的:
- 评估nAMD患者在6年内在T&E疗程中使用aflibercept实现并维持治疗结束的比例.
- 评估T&E治疗中的nAMD患者的现实结果,包括视力敏度和复发率.
主要方法:
- 对接受静脉注射aflibercept的治疗先的nAMD患者的回顾性图表审查.
- 最少2年的随访期,以评估治疗退出标准的遵守.
- 主要结局:达到并维持治疗结束的患者百分比;次要结局:最佳校正视敏度 (BCVA),复发发病率,治疗持续时间和注射间隔.
主要成果:
- 31个眼睛中的22.6% (25名患者) 达到治疗退出标准.
- 疾病复发发生在28.6%的患者中,他们达到退出,需要重新开始治疗.
- 中位BCVA保持稳定,直到第6年,它下降到0.4.4.
- 在6年内,注射频率下降,实现了更长的时间间隔.
结论:
- 与临床试验相比,使用aflibercept T&E实现治疗退出标准的现实世界水平较低.
- 治疗结束后的复发率与以前的发现相比较.
- 潜在的不遵守严格的T&E协议可能会影响治疗退出成功.
更多相关视频
07:04Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
Published on: February 4, 2021
2.0K
05:14Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
999
相关概念视频
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:28Angle Closure Glaucoma: Treatment
1.7K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
01:27Diabetic Retinopathy
66
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
66