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Updated: May 5, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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Published on: June 9, 2018

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使用人类大脑组织微阵列阐明皮质神经血管参与亨廷顿病

Adelie Y S Tan1, Lance C M G Martinez1, Helen C Murray1

  • 1Centre for Brain Research, University of Auckland, Auckland 1023, New Zealand; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1023, New Zealand.

Neurobiology of disease
|February 5, 2025
PubMed
概括

亨廷顿病 (HD) 显示大脑血管增加,与病理和早期症状有关. 然而,血脑屏障在受影响的皮质区域中仍然完好无损.

关键词:
人类大脑 人类大脑亨廷顿病就是亨廷顿病.中间状回环 中间状回环组织微阵列组织微阵列.血管系统 血管系统

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
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