相关实验视频
Updated: May 29, 2025
08:08
Isolation and Activation of Murine Lymphocytes
Published on: October 30, 2016
21.0K
蒂拉皮亚T细胞激活刺激信号分子CD2的功能研究
Yuan Li1, Zhi-Wen Wang2, Bei Wang2
1Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, 524088, Zhanjiang, Guangdong, China; College of Biology and Agriculture, Shaoguan University, 512005, Shaoguan, China.
Fish & shellfish immunology
|February 5, 2025
概括
研究人员确定了鱼CD2基因,这对T细胞激活至关重要. 这项研究揭示了CD2的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 鱼类生物学 鱼类生物学
- 分子生物学分子生物学
背景情况:
- 作为T细胞激活中的共刺激分子CD2的作用,在较低的脊椎动物中还没有得到充分研究.
- 有限的研究存在于CD2功能和鱼类免疫系统中的相互作用.
研究的目的:
- 为了识别和表征鱼CD2基因 (OnCD2).
- 为了研究鱼CD2及其连接体CD48.8之间的相互作用.
- 阐明OnCD2在T细胞激活和免疫调节中的作用.
主要方法:
- 提拉皮亚的基因鉴定和测序CD2.
- 在各种鱼免疫组织中进行表达分析.
- 基于磁珠的CD2阳性淋巴细胞的识别.
- 流细胞测量以评估CD2阳性细胞群的变化.
- 用CD2抗体和CD48重组蛋白刺激后的基因表达分析.
主要成果:
- 鉴定了小鱼儿CD2基因 (OnCD2),并发现它主要表达在免疫组织中.
- 蒂拉皮亚的CD2阳性淋巴细胞包括T辅助细胞 (Th),自然细胞毒性细胞 (NCC) 和B细胞.
- 用CD2抗体和CD48重组蛋白刺激与T细胞激活相关的上调基因.
- 在各种刺激下,CD2阳性细胞的比例在头,外围血液和脏淋巴细胞中增加.
结论:
- 提拉皮亚CD2通过与CD48.8的相互作用在T细胞激活中起着重要作用.
- OnCD2参与了在小症中复杂的免疫调节途径.
- 这项研究为鱼类免疫细胞分类提供了参考,并促进了对鱼类T细胞免疫力的理解.
相关概念视频
01:22T Cell Activation and Clonal Selection
638
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
638
01:24T Cell Types and Functions
939
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
939