美国向儿童和青少年发放 gabapentinoid
Andrew Terranella1, Xinyi Jiang1, Ceciley Bly2
1Division of Overdose Prevention, National Center for Injury Prevention and Control, CDC, Atlanta, Georgia.
American journal of preventive medicine
|February 5, 2025
概括
针对儿童和青少年的 gabapentinoid 处方正在增加,特别是在老年女性和通过护士从业人员中. 这一趋势凸显出需要仔细考虑儿科护理中的风险和益处.
科学领域:
- 儿科药理学 儿科药理学
- 青少年医学 青少年医学
- 公共卫生 公共卫生
背景情况:
- 加巴丁类药物越来越多地被非标签处方给儿科患者.
- 关于加巴类药物的使用和儿童和青少年的相关风险的数据有限.
- 担忧包括在这个人口群体中潜在的滥用和过量使用.
研究的目的:
- 为了确定对美国儿童和青少年开放 gabapentinoid 的程度.
- 根据年龄,性别和处方者专业分析 gabapentinoid 使用趋势.
主要方法:
- 利用了2017年4月至2023年9月的全国代表性零售药店发行数据 (IQVIA).
- 分析了发行趋势,季度平均利率 (MQR) 和季度百分比变化 (QPC).
- 检查的数据按患者年龄 (≤19岁),性别和处方者的专业分层.
主要成果:
- 总的来说, gabapentinoid 的发放率为 4534.9/100,000 人.
- 在2021年第二季度和2023年第三季度 (QPC=2.8) 之间,配送率显著增加 (QPC=2.8).
- 在青少年 (10-19岁) 和女性中观察到的最高率;执业护士占了最大的分发份额 (17.8%) 和显著增加.
结论:
- 美国儿童和青少年对 gabapentinoid 的使用明显增加.
- 进一步的研究应该调查处方因素和儿科疾病流行病学的发展.
- 临床医生必须仔细权衡在儿科患者处方 gabapentinoid 的风险和益处.
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