来自新西兰原生森林的的组成和生物活性
M Manley-Harris1, M N C Grainger1, L M Peters1
1School of Science, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.
Fitoterapia
|February 5, 2025
概括
新西兰在化学上不同,基于蜜蜂料. 本土植物产生富含迪特尔胺的,具有显著的生物活性,与影响的品种不同.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 植物学 植物学
背景情况:
- 由于隔离,新西兰的动植物是独一无二的,但欧洲殖民者引入了北半球的植物.
- 引入的蜜蜂 (Apis mellifera) 缺乏与本土植物的进化联系.
- 蜂的化学特征因蜜蜂食环境而异.
研究的目的:
- 为了研究从新西兰本土植物中获取的化学特征和生物活性.
- 为了比较来自本土植物的与受到北半球引入植物影响的.
- 确定负责的生物活性的关键化合物.
主要方法:
- 气色谱-质谱学 (GC-MS) 和核磁共振 (NMR) 谱学用于化合物表征.
- 来自蜂蜜在本地Te Urewera地区寻找食物的蜂粉的分析与带有引入植物的地区相比.
- 生物活性测定包括抗氧化能力 (TEAC),线粒体脱酶抑制,超氧化物生产抑制,以及对S. aureus的抗菌活性.
主要成果:
- 来自本土植物 (Te Urewera) 的蜂含有丁酸 (异压酸,乙异压酸,manool,torulosal,交流酸,ferruginol),与影响的蜂不同,它含有黄酸.
- "流行性" прополис显示出显著的抗氧化活性 (1481毫克托洛克斯g-1),剂量依赖的线粒体脱酶的抑制,以及超氧化物生产的抑制 (IC50 = 262μg mL-1).
- 抗微生物活性被观察到对甲基西林耐药和甲基西林敏感的金黄色葡萄球菌.
结论:
- 新西兰的土著植物产生一种独特的"本土",其特点是diterpenoids.
- 这些二甲类物质负责观察到的抗氧化,抗炎和抗菌生物活性.
- 地方性蜂与地中海和巴西蜂具有化学相似之处,这表明潜在的共享生物活性化合物.
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