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Updated: May 29, 2025

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在体外,O-GlcNAc的修饰差异性调节微管结合和tau异型体的病理构造

Mohammed M Alhadidy1, Paul M Stemmer2, Nicholas M Kanaan1

  • 1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, United States; Neuroscience Program, Michigan State University, East Lansing, Michigan, United States.

The Journal of biological chemistry
|February 5, 2025
PubMed
概括

在阿尔茨海默氏症中,O-GlcNAcylation对陶蛋白形状的影响不同. 这项研究表明O-GlcNAcylation影响tau的微管结合和病理形式,对4R和3Rtau异型有明显的影响.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.这是一种O-糖基化.聚合方式 聚合方式 聚合方式纤维丝是一种纤维丝.微管是微管中的一个.寡合物是指一些寡合物.酸酶激活域是一个主域.后翻译修改后的修改.蛋白质构成的结构.蛋白质的错误折叠 蛋白质的错误折叠重组蛋白质蛋白质的重组蛋白质是什么?知道的 知道的 知道的病症是一种病症.

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