红细胞体在脏活检和IgA脏病的进展
Yu-Xuan Yao1,2,3, Chen Tang1,2,3, Su- Fang Shi1,2,3
1Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
概括
脏红细胞造 (RBCC) 在IgA脏病 (IgAN) 中很常见,并表明脏的预后更好,特别是在用免疫抑制疗法 (IST) 治疗时. 对这些患者进行进一步的研究是有必要的.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 脏红细胞体 (RBCC) 经常在IgA脏病 (IgAN) 中观察到.
- 在IgAN进展中RBCC的预后意义仍然不完全理解.
- 了解RBCC的作用对于完善Igan患者管理至关重要.
研究的目的:
- 调查Igan患者的RBCC和结局之间的关联.
- 为了确定是否存在RBCC会影响疾病的进展和对治疗的反应.
- 为了澄清IGAN中RBCC的预后价值.
主要方法:
- 分析了两个队列:北京大学第一医院IGAN (PKU-IgAN) 和TESTING试验.
- 通过光显微镜识别体在管中的RBCC存在.
- 脏终点:通过考克斯回归评估的持续30%的eGFR下降,ESKD或脏死亡的复合.
主要成果:
- 在37%的PKU-IgAN和28%的TESTING试验患者中观察到RBCC.
- 与更多的新月病变和较少的细分性硬化症相关的RBCC.
- 在PKU-IgAN (HR 0.79,P=0.038) 和TESTING试验 (无变,HR 0.64,P=0.047) 中,RBCC独立预测了更好的复合结点.
- 在RBCC和免疫抑制疗法 (IST) 之间有显著的相互作用 (P=0.001);RBCC预测IST的结果更好 (HR0.56,P<0.001).
结论:
- 脏RBCC在Igan中很常见,并且与急性活性病变有关.
- RBCC与更好的脏预后有关,特别是在接受国际输血病毒治疗的患者中.
- 对于优化Igan治疗策略,需要密切关注RBCC的存在.
更多相关视频
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
2.8K
14:18Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
Published on: October 13, 2023
1.7K
相关概念视频
01:20Renal Corpuscle
1.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.6K
01:45Kidney Structure
68.7K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
68.7K
01:10Nephrons
2.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.1K