在婴儿期发展的小脑和大脑皮层功能连接架构
Sankalp Tikoo1, Carlos R Hernandez-Castillo2, Haitao Chen1,3
1Department of Biomedical Sciences and Imaging, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.
概括
小脑是小脑的组成部分.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 儿科神经学 儿科神经学
背景情况:
- 小脑的作用超出了运动控制范围,涉及到诸如认知和情绪之类的高阶功能.
- 小脑的功能架构对婴儿发育至关重要,但研究不足.
- 在了解生命早期的纵向小脑发育方面存在研究差距.
研究的目的:
- 在婴儿中绘制小脑功能连接的发展轨迹.
- 为了研究小脑内和大脑皮层之间的连接.
- 为了比较完整期和早产婴儿之间的功能发育.
主要方法:
- 在生命的头两年中,对222名婴儿 (155名满期,67名早产) 进行了长度研究.
- 分析小脑内以及小脑与皮质之间的功能连接.
- 完整期和早产婴儿之间的连接模式的比较.
主要成果:
- 新生儿小脑表现出高度的内部同步,主要投射到感觉运动和视觉皮层.
- 从出生到2岁,小脑内同步是稳定的;大脑皮层连接是动态成熟的.
- 与满期婴儿相比,早产婴儿的脑皮层连接性减少.
结论:
- 小脑的功能组织在早期发育过程中内部是稳定的,但在皮质连接中是可塑的.
- 大脑皮层路径的动态成熟表明早期参与更高层次的功能.
- 早产婴儿的连接性改变可能会影响长期的认知和社会情感发展.
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