饮食葡萄糖指数和负载在怀孕期间和后代的行为结果:探索性别差异
Esther Cendra-Duarte1,2, Josefa Canals1,3,4, Nerea Becerra-Tomás1,3
1Universitat Rovira i Virgili, Unitat de Salut Pública i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) Research Group, Reus, Spain.
European journal of pediatrics
|February 5, 2025
概括
怀孕早期母亲高血糖负荷与4岁儿童,特别是女孩的行为问题有关. 没有发现与血糖指数或晚期怀孕饮食的关联.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 营养科学 营养科学
背景情况:
- 在怀孕期间,碳水化合物摄入对于胎儿大脑发育至关重要.
- 虽然产前高血糖指数 (GI) 和高血糖负荷 (GL) 与不良结果有关,但它们对后代行为的具体影响尚不清楚.
- 新出现的证据表明,母亲的GL和儿童的行为问题之间存在潜在联系,可能存在性别特异性的脆弱性.
研究的目的:
- 调查孕期早期和晚期的孕妇血糖指数 (GI) 和血糖负荷 (GL) 与4岁儿童的行为问题之间的关联.
- 探索在妊娠期间对母亲饮食的后代易感性的潜在性别相关差异.
主要方法:
- 这是一项观察性研究,涉及来自ECLIPSES研究的188对母婴对.
- 使用经过验证的食物频率调查问卷来评估母亲的GI和GL.
- 用儿童行为检查表 (CBCL 1.5-5) 评估后代的行为,并进行多变量回归分析.
主要成果:
- 妊娠第一季度母亲GL升高与儿童内化,外化,总和自闭症谱系问题增加有关.
- 这些关联在女性后代中更为明显.
- 在孕期第三季度的母体GL或母体GI (在任何阶段) 与儿童行为之间没有观察到显著的关联.
结论:
- 在怀孕早期,母亲的高血糖负荷与后代的不良行为结果有关.
- 这些发现强调了孕早期母亲饮食成分对儿童神经发育的重要性.
- 雌性后代可能更容易受到母亲高血糖负荷的影响.
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