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Updated: May 29, 2025

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一个双基活性胚胎增强剂决定了GNAS通过基特异性构造的印记

Yorihiro Iwasaki1,2, Monica Reyes1, Harald Jüppner1,3

  • 1Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Nature communications
|February 5, 2025
PubMed
概括

对基因表达至关重要的基因印记被STX16微切除所破坏,导致类型-1B的伪偏偏甲状腺症. 这项研究揭示了胚胎增强剂如何通过异位基因特异性染色体构造来决定GNAS印记.

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