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Updated: May 29, 2025

Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation
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Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

Published on: February 2, 2016

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种子选择能够高效丰富在多个位置编辑的初级T细胞

Christopher R Chang1,2,3,4, Vivasvan S Vykunta1,2,3,4, Jae Hyun J Lee1,5

  • 1Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.

Nature biotechnology
|February 5, 2025
PubMed
概括

这项研究引入了合成外表激素表达干扰剂 (SEEDs),以有效地产生纯粹的多基因编辑T细胞. 这一单步的SEED-Selection过程通过丰富精确的工程细胞来增强细胞疗法制造.

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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

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Author Spotlight: Efficient CRISPR/Cas9 Genome Editing in Bone Marrow-Derived Macrophages for Precise Gene Disruption04:51

Author Spotlight: Efficient CRISPR/Cas9 Genome Editing in Bone Marrow-Derived Macrophages for Precise Gene Disruption

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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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