青年大麻使用障碍的N-乙半氨酸:随机对照试验的主要发现
Kevin M Gray1, Rachel L Tomko2, Nathaniel L Baker3
1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA. graykm@musc.edu.
概括
在没有应急管理的情况下提供时,N-乙半氨酸并没有改善青少年大麻使用障碍的结果. 这凸显了行为干预在治疗青少年大麻使用障碍方面的重要性.
科学领域:
- 药物成 药物成 药物
- 青少年精神病学 青少年精神病学
- 药理干预措施 药理干预措施
背景情况:
- 大麻使用障碍 (CUD) 是青少年的一个重大公共卫生问题,基于证据的治疗选择有限.
- 之前的研究表明,当与应急管理相结合时,N-乙半氨酸 (NAC) 对青年的CUD有效.
- 目前的研究旨在评估NAC在没有强大的行为干预平台的情况下对患有CUD的青少年的有效性.
研究的目的:
- 严格评估N-乙半氨酸作为青少年大麻使用障碍的独立治疗的疗效.
- 为了确定N-乙半氨酸是否改善了CUD青少年的治疗结果,与安慰剂相比.
主要方法:
- 一个双盲,随机对照试验,涉及192名正在寻求治疗的青少年 (14-21岁) 患有CUD.
- 参与者接受了12周的口服N-乙半氨酸 (1200毫克每天两次) 或安慰剂,以及每周的医疗管理和简短的行为咨询.
- 主要结局是尿液中阴性大麻素测试的比例;次要结局包括自我报告的大麻使用和戒断.
主要成果:
- 在N-乙半氨酸和安慰剂组之间,在阴性尿液测试或自我报告的大麻戒断的比例方面没有发现显著差异.
- 两组都显示大麻使用日数和数量随着时间的推移而下降,但群体差异并不显著.
- 与安慰剂组相比,N-乙半氨酸组的胃肠道不良事件更为频繁.
结论:
- 如果不与强大的行为治疗平台集成,例如应急管理,那么N-乙半氨酸对于治疗青少年大麻使用障碍是无效的.
- 这些发现强调了行为干预在提高青少年CUD药理疗法的有效性方面的关键作用.
- 未来的研究应该专注于结合疗法,将行为和药理方法整合到青年CUD中.
更多相关视频
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.5K
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
14.7K
相关概念视频
01:30Attention-Deficit/Hyperactivity Disorder
35
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
35
01:27CNS Depressants: Alcohol and Nicotine
170
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
170